A Study of Neutrophil Hyper Segmentation in Elderly and its Diagnostic Value for Cobalamin and Folic Acid Deficiency in Mashhad, Iran
L
Manavifar
عضو هیئت علمی دانشکده پیراپزشکی ، کارشناس ارشد خون شناسی و بانک خون
author
A
Nejat shokouhi
گروه بیوشیمی وتغذیه، دانشکده پزشکی دانشگاه علوم پزشکی مشهد
author
Hossein
ayatollahi
دکترای تخصصی پاتولوژی- دانشیار گروه داخلی دانشکده پزشکی،دانشگاه علوم پزشکی مشهد
author
M
Mahjoub
عضو هیئت علمی دانشکده پیراپزشکی ،دانشگاه علوم پزشکی زاهدان
author
text
article
2012
per
Introduction: The prevalence of cobalamin and folic acid is high in elderly. Ambiguous clinical findings, various laboratory methods and normal range and cost of laboratory tests have been resulted in complexity and delay of the deficiency diagnosis. The aim of this study is to evaluate the relation between hematologic parameters, especially neutrophil hypersegmentation and cobalamin andfolic acid insufficiency as well as increased serum hemocystein. Methods: Three hundred subjects more than 65 years age from twelve regions of Mashhad were studied. This population was selected by the Provincial Health Center. 250 subjects were analyzed for serum cobalamin and folate by RIA method. 78 subjects, who had cobalamin 120-450 pg/ml and folate 1.5-17ng/ml without any confounders, were analyzed for homocystein (Hcy) by Elisa method. Hematological parameters were assayed by H1 system and blood smear by microscopic observation. Data were analyzed by SPSS 11.5 software.
Results: Among 235 participants, 45.5% and 54.5% were positive and negative for neutrophil hypersegmentation (NH), respectively. Significant correlation was not found between NH and gender. In 216 subjects, 56.7% had red blood cell macrocytosis. There was a significant relation between severity of NH and macrocytosis (p=0.001). Macrocytosis had significant correlation with folate deficiency (p=0.017). NH showed a statistically significant relation with folate (p=0.036), however, no correlation with cobalamin
Conclusion: With respect to the high incidence of folate deficiency in elderly, a simple and economic screening test such as NH and macrocytosis could be performed for evaluation of serum folate. Although the specificity and sensitivity of NH for diagnosis of folate deficiency is not high, it may be used as a screening test.
Journal of Paramedical Sciences & Rehabilitation
Mashhad University of Medical Siences
2322-5238
1
v.
1
no.
2012
8
14
https://jpsr.mums.ac.ir/article_31_b8981a3ecba5b3b674a0e0f4d859aa62.pdf
dx.doi.org/10.22038/jpsr.2012.31
Evaluation of the Effect of Daily Work and Resultant Tiredness on Near Steroacuity in Intermittent Exotropic Patients
J
Heravian
استاد اپتومتری دانشگاه علوم پزشکی مشهد
author
A.A
Yekta
استاد اپتومتری دانشگاه علوم پزشکی مشهد
author
H
Ostadimoghddam
دانشیار اپتومتری دانشگاه علوم پزشکی مشهد
author
A
Azimi
دانشیار اپتومتری دانشگاه علوم پزشکی مشهد
author
M.J
Khoshsima
دانشگاه علوم پزشکی مشهد دانشکده پیراپزشکی گروه بینایی سنجی کارشناس بینایی سنجی
author
M
Shabani
دانشگاه علوم پزشکی مشهد دانشکده پیراپزشکی گروه بینایی سنجی کارشناس بینایی سنجی
author
E
Khanpour
دانشگاه علوم پزشکی مشهد دانشکده پیراپزشکی گروه بینایی سنجی کارشناس بینایی سنجی
author
Z
Salahi
دانشگاه علوم پزشکی مشهد دانشکده پیراپزشکی گروه بینایی سنجی کارشناس بینایی سنجی
author
H
Hosseini yazdi
دانشگاه علوم پزشکی تهران دانشکده توانبخشی گروه بینایی سنجی کارشناس ارشد بینایی سنجی
author
text
article
2012
per
Introduction:
Variations in sterioacuity may be used in an assessment of intermittent exotropia. Intermittent exotropia is divergent squint of eyes that is worsened due to daily visual tasks and its resultant tiredness therefore the amount of deviation increases. The purpose of this study is to determine the effect of daily work and resultant tiredness on near sterioacuity among intermittent exotropic patients.
Methods:
In this cross-sectional study, 600 dormitory students of Mashad University of Medical Sciences, ranging in age from 21 to 23 years, examined with alternate cover test to diagnose intermittent exotropic cases. 30 students had intermittent exotropia and along with 15 normal cases constituted the case-control group. Sterioacuity was measured twice, in the morning and at night, with Randot-SO 001 test. Suppression was checked with Bagoloni striate lens and 4 prism diopter base out test. Data were statistically analyzed with SPSS software (version 13).
Results:
The measured deviation in intermittent exotropic cases showed a significant difference between the deviation in the morning and late at night among 23.33% (7 cases) (P=0.00). In addition, sterioacuity decreased significantly at night, (P=0.00) among these cases. Despite the increase in the deviation among 53.3% (16 cases) at night, steriacuity was not changed significantly. 23.33% (7 cases) did not show any changes in the morning and at night, both in deviation amount and sterioacuity measurement.
Conclusion:
In most intermittent exotropic cases, there is no significant correlation between intermittent exotropia and near sterioacuity variations after daily work and resultant tiredness (P<0.696).
Journal of Paramedical Sciences & Rehabilitation
Mashhad University of Medical Siences
2322-5238
1
v.
1
no.
2012
15
22
https://jpsr.mums.ac.ir/article_71_f5cb71887fb1b73b1f1ed47bff8d824c.pdf
dx.doi.org/10.22038/jpsr.2012.71
Effect of Bobath,s Therapeutic Approach on Spasticity and Quality of Movement Patterns in Hemiplegic Patients
M
Shaikh
استادیار دانشکده پیراپزشکی دانشگاه علوم پزشکی مشهد ، دکتری تخصصی فیزیوتراپی
author
H.A
Hosseini
استادیار دانشکده پیراپزشکی دانشگاه علوم پزشکی مشهد ، دکتری تخصصی فیزیوتراپی
author
G.R
Olyaee
استاد دانشکده توانبخشی دانشگاه علوم پزشکی تهران ، دکتری تخصصی فیزیوتراپی
author
N
Nokhostin Ansari
دانشیار دانشکده توانبخشی دانشگاه علوم پزشکی تهران ، دکتری تخصصی فیزیوتراپی
author
S
Talebian Moghddam
دانشیار دانشکده توانبخشی دانشگاه علوم پزشکی تهران ، دکتری تخصصی فیزیوتراپی
author
text
article
2012
per
Introduction: Hemiplegia is a complication, results from upper motor neuron lesions and is usually associated with spasticity and movement disorders. To control spasticity and accomplish functional activities, several approaches have been presented such as Neurodevelopment treatment (NDT), according to Bobath,s assumptions. Although lower limb spastic hemiplegia is common and its management is time-consuming, in this study we were intended to examine the effectiveness of this therapeutic approach on spasticity management and quality of lower limb movement patterns. Methods: Fifteen hemiplegic patients (age range, 44-75) participated in this study. Baseline assessments before and after the treatment included: spasticity measurement of plantar flexor muscles of ankle according to the Original Ashworth Scale (OAS), measurement of active and passive range of motion of ankle dorsiflexion and defining the quality of lower limb movement patterns according to "Standing test" of Bobath,s approach. Results: Following intervention (20 sessions), there was a significant decrease in spasticity and a significant increase in an active and passive range of motion and quality of movement patterns. Conclusion: According to the obtained results, by modification of excitation – inhibition in CNS and transmitting it to the peripheral region (muscles), Bobath’s approach can reduce the spasticity of plantar flexor muscles, subsequently, the dorsiflexion range of motion increases. Indeed, this therapeutic approach increases coordination in movement patterns and improves quality of movement patterns by retraining balance in various positions. Results of this study may be used extensively in management of patients with upper motor neuron lesion referred to rehabilitation centers.
Journal of Paramedical Sciences & Rehabilitation
Mashhad University of Medical Siences
2322-5238
1
v.
1
no.
2012
23
29
https://jpsr.mums.ac.ir/article_246_e63acdb1c5fa1760ab89df4f1f1b4205.pdf
dx.doi.org/10.22038/jpsr.2014.246
Determination of the Inhibitory Mechanism of Eugenyl Adamantate on 15-Lipoxygenase
M
Davood Nejad
گروه علوم آزمایشگاهی، دانشکده علوم پیراپزشکی، دانشگاه علوم پزشکی مشهد
author
M
Alimardan
گروه علوم آزمایشگاهی، دانشکده علوم پیراپزشکی، دانشگاه علوم پزشکی مشهد
author
H
Sadeghian
استادیار گروه علوم آزمایشگاهی، دانشکده علوم پیراپزشکی، دانشگاه علوم پزشکی مشهد
author
text
article
2012
per
Introduction:
Lipoxygenases are non-hem iron-containing proteins responsible for the peroxidation of the unsaturated lipids in animals and plants. The critical role of the enzymes in creating inflammations, sensitivities and some of the cancers has been demonstrated in mammalians. An investigation of the mechanism details of these category of enzymes and the metabolism of their peroxide products as well as the synthesis of appropriates inhibitors is of great importance for the mentioned enzymes. In this article, the inhibitory mechanisms of eugenyl adamantate which is a new synthetic potent inhibitor of lipoxygenase is studied.
Methods:
The lipoxygenase activity of soybean 15-lipoxygenase in the presence of eugenyl adamantate was assayed by using two spectrophotometric methods: the formation of conjugated dien in 235 nm and DMAB-MBTH peroxide in 592 nm.
Results:
The experiments show that the mentioned compound decreases the lipoxygenase activity in two concentration ranges of 80-120 nM and 5-13 µM. The kinetic studies show the mixed inhibitory mechanism including the competitive and non-competitive for this compound.
Conclusion:
The kinetic studies show the mixed inhibitory mechanism of the compound.
Journal of Paramedical Sciences & Rehabilitation
Mashhad University of Medical Siences
2322-5238
1
v.
1
no.
2012
30
34
https://jpsr.mums.ac.ir/article_255_c9bb7254724059a26d6a7afb3f17927b.pdf
dx.doi.org/10.22038/jpsr.2012.255
Evaluation of an Awareness of Clinical Information Systems among the Staff of Medical Records Departments of Hospitals Affiliated to the Tehran University of Medical Sciences, 2011
G.R
Moradi
استادیار، دکترای مدیریت اطلاعات بهداشتی و درمانی،عضو هیات علمی دانشگاه علوم پزشکی مشهد
author
S
Fazaeli
دانشجوی دکترای مدیریت اطلاعات بهداشتی و درمانی و مدرس دانشگاه علوم پزشکی مشهد
author
M
Meraji
دانشجوی دکترای مدیریت اطلاعات بهداشتی و درمانی و مدرس دانشگاه علوم پزشکی مشهد
author
Kh
Kimiafar
مربی، دانشجوی دکترای مدیریت اطلاعات بهداشتی و درمانی، دانشگاه علوم پزشکی مشهد
author
M
Sarbaz
مربی، دانشجوی دکترای انفورماتیک پزشکی، دانشگاه علوم پزشکی مشهد
author
Z
Ershadnia
کارشناس مدارک پزشکی، دانشجوی کارشناسی ارشد فناوری اطلاعات
author
text
article
2012
per
Introduction: The information gathered in hospitals for clinical services is massive and management of this dispersed information is very complicated, however, necessary for medical centers. Considering the computer capabilities, clinical information systems are very useful and efficient in achieving the management goals in medical centers. This study was conducted for evaluating different applications of clinical information systems and staff awareness of Medical Records Department. Methods: This study was conducted in two-steps: In the first step, the available resources during 2000-2011 were studied. In the second step, awareness of clinical information systems among Medical Record Department's staff of Tehran University of Medical Sciences hospitals has been evaluated. The validity of the questions raised in questionnaire was confirmed by the expert panel and its reliability was determined to be 80% by test-retest coefficient. The collected data was analyzed using MS Excel 2007 software. Results: The clinical information system consists of different parts and a variety of applications including: clinical documentation, making decision, management of medicine, radiology, laboratory, etc. There are barriers such as financial, behavioral and technical issues to employ these systems. The results obtained from the second part showed that the average of staff awareness of clinical information systems was 49%. Conclusion: Considering the numerous benefits of clinical information systems, using it for supplying information on clinical centers is an inevitable necessity. Selecting a proper system, training users, and paying attention to the factors affecting their implementation in hospitals play a key role in its clinical effectiveness and widespread use of clinical information systems.
Journal of Paramedical Sciences & Rehabilitation
Mashhad University of Medical Siences
2322-5238
1
v.
1
no.
2012
35
42
https://jpsr.mums.ac.ir/article_257_b89e112fc5f94f5a34bab470c4475f25.pdf
dx.doi.org/10.22038/jpsr.2012.257
The Antibiotic Resistance Pattern of Staphylococcus aureus Isolated From Patients in Quaem University Hospital During 2009-2011
H
Safdari
مربی، عضو هیات علمی دانشکده پیراپزشکی
author
A
Sadeghian
استاد دانشکده پزشکی، پژوهشکده بوعلی
author
S
Tahaghoghi
کارشناس علوم آزمایشگاهی مرکز بهداشت
author
text
article
2012
per
Introduction:
Staphylococcus aureus is a major human pathogen. Due to the high prevalence of S. aureus infections and increasing resistance to antibiotics, physicians have been facing problems in choosing an appropriate empirical antibiotic therapy. The aim of this study was to determine the pattern of antibiotic resistance among S. aureus clinical isolates in Quaem university hospital between 2009 and 2011.
Methods:
In this study 100 isolates of Staphylococcus aureus were identified in laboratory from different specimens. The specimens were collected and examined by standard diagnostic methods. Determination of S. aureus sensitivity to antibiotics was performed using standard disc diffusion method. The antibiotic sensitivity of bacteria were reported according to the Clinical Laboratory Standards Institute (CLSI) manual with sensitive (S), intermediate (I) and resistant (R).
Results:
Among antibiotics tested, Staphylococci isolates were highly resistant against Penicillin 97%, followed by, Oxacillin 63% Erythromycin 57%, Cephalexin 43% Clindamycin 33 % Vancomycin 20%.
Conclusion:
Our results are similar to the reports from many other parts of Iran. According to this study, resistance pattern among Staphylococcus aureus strains was widespread in Quaem hospital. The implication of this high resistance is that Staphylococcus aureus infections should be treated with more precaution and not with Penicillin and other ineffective antibiotics.
Journal of Paramedical Sciences & Rehabilitation
Mashhad University of Medical Siences
2322-5238
1
v.
1
no.
2012
43
46
https://jpsr.mums.ac.ir/article_258_0811be73e73b7832f786913b927ae302.pdf
dx.doi.org/10.22038/jpsr.2012.258
The Prevalence of Congenital Color Blindness and its Effect on Contrast Sensitivity and Depth Perception
H
Ostadimoghaddam
دانشیار اپتومتری دانشکده علوم پیراپزشکی ، دانشگاه علوم پزشکی مشهد
author
A
Azimi
دانشیار اپتومتری دانشکده علوم پیراپزشکی ،دانشگاه علوم پزشکی مشهد
author
J
Heravian
استاد اپتومتری دانشکده علوم پیراپزشکی، دانشگاه علوم پزشکی مشهد
author
A.A
Yekta
استاد اپتومتری دانشکده علوم پیراپزشکی، دانشگاه علوم پزشکی مشهد
author
f
Sharifi
کارشناس ارشد اپتومتری دانشکده علوم پیراپزشکی ، دانشگاه علوم پزشکی مشهد
author
M
Khbazkhoob
کارشناس ارشد اپیدمیولوژی مرکز چشم پزشکی نور
author
M.J
Khoshsima
کارشناس اپتومتری دانشکده علوم پیراپزشکی ، دانشگاه علوم پزشکی مشهد
author
M
Hasheminjad
کارشناس اپتومتری دانشکده علوم پیراپزشکی ، دانشگاه علوم پزشکی مشهد
author
P
Razavi
کارشناس اپتومتری دانشکده علوم پیراپزشکی ، دانشگاه علوم پزشکی مشهد
author
text
article
2012
per
Introduction: Color blindness is a common disorder. The congenital type of tcolor blindness is sex-linked and the genes are located on the X chromosome. The prevalence of color blindness among males and females are 5-8 % and 0.5 %, respectively. Color blindness may affect daily activities and could be considered as a disability. Therefore, the aim of this study was to investigate the prevalence of color blindness and its effect on contrast sensitivity and depth perception among school children in Mashhad. Methods: Four thousand four hundred school children (2408 males and 1992 females) were selected randomly and tested by Ishihara for color blindness detection. At the second step, students with color blindness were examined at optometry clinic by the Ishihara test again. Two hundred students were also selected randomly to allocate into a control group. Cambridge and Titmouse tests were taken on the case and control groups. Results: Among 4400 schoolchildren, 3% suffered from color blindness (5.1% in boys and 0.4% in girls). Ishihara test showed 2.2% deuteranopia, 0.8% protanopia and 0.6% suspect. The results indicate that the congenital color blindness has no significant effect on contrast sensitivity and depth perception. Conclusion: The present report provides valuable information regarding color vision defectiveness among schoolchildren. Effective detection of this anomaly is expected to prevent from substantial effects on their education and future job. It is strongly recommended to perform color vision test at the beginning of a child’s education.
Journal of Paramedical Sciences & Rehabilitation
Mashhad University of Medical Siences
2322-5238
1
v.
1
no.
2012
47
52
https://jpsr.mums.ac.ir/article_259_17480c8fc5fb7ce1bc47bb06b3fe52ec.pdf
dx.doi.org/10.22038/jpsr.2012.259