Vitamin D3 Deficiency among Mentally Disabled Patients City of kashmar in 2016

Document Type : Original Article

Authors

1 Student of General Medicine, Faculty of Medicine, Gorgan University of Medical Sciences, Gorgan, Iran

2 Kashmar Higher Health Education Complex, School of Nursing, Mashhad University of Medical Sciences, Mashhad, Iran

3 Facaulty Member, Kashmar Center of Higher Health Education, Mashhad University of Medical Sciences, Mashhad, Iran

4 Department of Microbiology, Kashmar Higher Health Education Complex. Mashhad University of Medical Sciences, Mashhad, Iran

5 Genetics, Neyshabour Azad University, Neyshabour, Iran

Abstract

Purpose:
Previous studies have indicated that vitamin D3 deficiency is common in mentally disabled. This study aimed to determine Vitamin D3deficiency among mentally disabled patients city of Kashmar.
Methods:
In this descriptive cross-sectional study, 72 mentally disabled people (10-60 years old) who were in a rehabilitation center in Kashmar city were selected through a census. Sampling was done by a researcher for subjects who had inclusion criteria. Serum levels of D3  were measured using HPLC method. The vitamin D3 deficiency was defined as serum 25-hydroxyvitamin D3 level ≤ 12 ng/ml. Data was analyzed using SPSS software.
Results:
47.2% patients were classified as deficient in Vitamin D3. Age and 25-hydroxyvitamin D3 level was significantly correlated. 65 percent of disabled from age 20 to 39 years were severe and moderate deficient in Vitamin D3.
Conclusion:
The physicians, responsible for the treatment of patients with multiple complex developmental disorder, incorporate Vitamin D3   supplementation in their practice. In addition, screening for vitamin D3 deficiency should be integrated in the health assessment of patients with mental disorders.

Keywords


  1. Hatami G, ahmadi s, motamed n, eghbali ss,et al. 25-oh vitamin d serum level in pregnant women in bushehr-2012 ṭibb-i junūb. 2014; 16(6): 408-410.
  2. Mithal A, wahl da, bonjour j-p, burckhardt p, et al. global vitamin d status and determinants of hypovitaminosis d. osteoporosis international 2009; 20(11): 1807-1820.
  3. Holick MF. vitamin d deficiency. new england journal of medicine 2007; 357(3): 266-281.
  4. Hashemipour S, larijani b, adibi h, javadi e, et al. vitamin d deficiency and causative factors in the population of tehran. bmc public health 2004; 4(1): 38-39.
  5. Heshmat R, mohammad k, majdzadeh s, forouzanfar m, et al. vitamin d deficiency in iran: a multi-center study among different urban areas. Iran J Public health 2008; 37(1): 72-78.
  6. Anneren G, johansson e, lindh u. trace element profiles in individual blood cells from patients with down's syndrome. acta pædiatrica 1985; 74(2): 259-263.
  7. Fung EB, samson-fang l, stallings va, conaway m, et al. feeding dysfunction is associated with poor growth and health status in children with cerebral  palsy. journal of the american dietetic association 2002; 102(3): 361-373.
  8. Chakrabarti S, fombonne e. pervasive developmental disorders in preschool children. jama 2001; 285(24): 3093-3099.
  9. Malekshahi F, fallahi s. parent’s mentally retarded child psycho-social problems covered by welfare centers khorramabad  2016; 18(3): 42-51.
  10. Nagpal S, na s, rathnachalam r. noncalcemic actions of vitamin d receptor ligands. endocr rev 2005; 26: 662-687.
  11. Holick M F.vitamin d deficiency.n engl j med 2007; 357: 266-281.
  12. Dawson-hughes b. serum 25-hydroxyvitamin d and functional outcomes in the elderly. am j clin nutr. 2008; 88(2): 537s-540s.
  13. El-hajj fuleihan g, nabulsi m, choucair m, et al. hypovitaminosis d in healt schoolchildren. pediatrics 2001; 107(4): e53.
  14. Fathi m. incidence rate and sources of stress among nurses working in intensive care unit of kurdistan university of medical sciences. sci j kurdistan univ med sci 2004; 7(28): 53-62.
  15. Imani e, khademi z, soudagar s, naghizadeh f. health status of nursing students of hormozgan university of medical sciences by goldberg’s general health questionnaire-2011. hormozgan medical journal 2013; 17(4): 357-364.
  16. Bischoff-ferrari ha, giovannucci e, willett wc, dietrich t, dawson-hughes b. estimation of optimal serum concentrations of 25-hydroxyvitamin d for multiple health outcomes. the american journal of clinical nutrition 2006; 84(1): 18-28.
  17. Mirsaeidy ghazi aa, r.z., pezeshk p, azizi f. seasonal variation of serum 25 hydroxy D3  in residents of tehran. J Endocrinol Invest 2004; 27(7): 676-679.
  18. Lips p. vitamin d status and nutrition in europe and asia. the journal of steroid biochemistry and molecular biology 2007; 103(3-5): 620-625.
  19. Pearce sh, cheetham td. diagnosis and management of vitamin d deficiency. bmj 2010; 340: b5664.
  20. Holick mf, siris es, binkley n, et al. prevalence of vitamin d inadequacy among postmenopausal north american women receiving osteoporosis therapy.j clin endocerinol metab 2005; 90: 3215-3224.
  21. Sadinia a, larijani b, jalalinia s, farzadfar f, et al. study of the prevalence of vitamin d deficiency in the iranian population living in the islamic republic of iran by province in the period of 2010-2010. journal of diabetes and metabolism of iran 2013; 12(6): 574-584.
  22. Sullivan ss, rosen cj, halteman wa, chen tc, holick mf. adolescent girls in maine are at risk for vitamin d insufficiency. journal of the american dietetic association 2005; 105(6): 971-974.
  23. Cengiz m, seven m, cengiz s, yuksel a, iscan m. vitamin and mineral status in down syndrome. trace elements and electrolytes 2000;  17(3): 156-160.
  24. Bax m. nutrition and disability. developmental medicine & child neurology 19936; 35(12): 1035-1036.
  25. Tompsett j, yousafzai a, filteau s. the nutritional status of disabled children in nigeria: a cross-sectional survey. european journal of clinical nutrition 1999; 53(12): 915.
  26. Srikanth r, cassidy g, joiner c, teeluckdharry s. osteoporosis in people with intellectual disabilities: a review and a brief study of risk factors for osteoporosis in a community sample of people with intellectual disabilities. journal of intellectual disability research 2011; 55(1): 53-62.
  27. Abdoullahi m. the comparative study of social damages among students with regarding western and islamic lifestyles. islamic social studies 2017; 1(108): 161-190.
  28. Bagherikarachi a, mehrabi a. comparing attitudes toward social harm in students based on family backgrounds. journal management system 2017; 4: 71-96.
  29. Adachi a, kobayashi t. identification of vitamin D3  and 7-dehydrocholesterol in cow's milk by gas chromatography-mass spectrometry and their quantitation by high-performance liquid chromatographyi. journal of nutritional science and vitaminology 1979; 25(2): 67-78.
  30. Grammatikopoulou mg, manai a, tsigga m, tsiligiroglou- fachantidou a, galli- tsinopoulou a, zakas a. nutrient intake and anthropometry in children and adolescents with down syndrome- - a preliminary study. dev neurorehabil.2008; 11: 260-267.
  31. Moradzadeh K, larijani B, Keshtkar A, etal. Normal values of vitamin D and vitamin D deficiency in Iranian. Journal of Kurdistan University of Medical Sciences 2006; 10: 33-43.[Persian].
  32. Kohsali m, mirzamani sm, mohammadkhani p, karimloo m. comparison of social adjustment in mothers of educable mentally retarded daughter. j behav sci 2008; 2(2): 165-172.
  33. Maghbooli z, ah-na, ali reza shafaei ar, karimi f, and l.b. madani fs, vitamin dstatus in mothers and their newborns in iran. bmc pregnancy and childbirth 2007; 7(1): 1.
  34. Shabayek mm. assessment of the nutritional status of children with special needs in alexandria. part ii: anthropometric measures. j egypt public health assoc. 2004; 79: 363- 382.
  35. hawn j, rice c, nichols h, mcdermott s. overweight and obesity among children with down syndrome: a descriptive study of children attending a down syndrome clinic in south carolina. j s c med assoc. 2009; 105(2): 64- 68.
  36. Ginde Adit A. Demographic Differences and Trends of Vitamin D Insufficiency in the US Population, 1988-2004. Arch Intern Med; 2009; 169(6):626-632.