Purpose: Diabetes is a common disorder which contributes to a variety of complications such as deficits in central auditory nervous system (CANS). Auditory late latency response (ALLR) is a well-established neurophysiological approach in the assessment of CANS performance. This study was aimed to compare ALLR in insulin dependent (Type I) diabetic patients and normal individuals. Methods: In this descriptive analytical and non-interventional study, ALLR was measured by using tone burst 1000 Hz on 25 Type I diabetic patients and 25 age, education and sex matched healthy controls include 12 males and 13 female in both groups, with mean age 28.76±4.1 year in patients and 29.68±3.6 year in controls. Data were analyzed by t-test and Pearson correlation tests using SPSS 17 software. Results: The mean ALLRs latency and amplitude of the diabetic patients were significantly different when compared with that of normal controls in both genders (p<0.01). Also, there was a strong correlation between ALLR latency and HbA1c and diabetes duration (p<0.01). Conclusion: Significant prolongation in latency and significant reduction in amplitude of ALLRs in the diabetic patients shows that cortical auditory information processing is slower than normal individuals.
Fauci AS, Kasper DL, Longo DL, Braunwald E, et al. Principles of Harrison's internal medicine. 17thEd. New York: McGraw Hill 2008; 2187-2416.
Alvarenga K De F, Duarte JL, da Silva DPC, Agostinho-Pesse RS, Negrato CA, Costa OA. Cognitive P300 potential in subjects with diabetes mellitus. Braz J Otorrinolaringol 2005; 71 (2): 202-207.
Sima AAF, Kamiya H, Guo Li Z. Insulin, C-peptide, hyperglycemia, and central nervous system complications in diabetes. Eur J Pharmacol 2004; 490(1-3): 187-197.
Alvarez EO, Beauquis J, Revsin Y, Banzan AM, et al. Cognitive dysfunction and hippocampal changes in experimental type 1 diabetes. Behav Brain Res 2009; 198(1): 224-230.
Tanriverdi F, Yapislar H, Karaca Z, Unluhizarci K, et al. Evaluation of cognitive performance by using P300 auditory event related potentials (ERPs) in patients with growth hormone (GH) deficiency and acromegaly. Growth Horm IGF Res 2009; 19(1): 24-30.
Lisowska G, Namysłowski G, Morawski K, Strojek K. Early Identification of Hearing Impairment in Patients with Type 1 Diabetes Mellitus. Otol Neurotol 2001; 22(3): 316-320
Patterson CC, Dahlquist GG, Gyürüs E, Green A, et al. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009; 373(9680): 2027-2033.
Perez AP, Ziliotto K, Pereira LD. Test-retest of long latency auditory evoked potentials (P300) with pure tone and speech stimuli. International archives of otorhinolaryngology. 2017; 21: 134-9
Hall III JW. New handbook of auditory evoked responses. Ed, Boston: Pearson 2006; 518-547.
Shehata G, Eltayeb A. Cognitive function and event related potentials in children with type I diabetes mellitus. J Child Neurol 2010; 25(4): 469-474.
Seraji H, Mohammadkhani G, Nasliesfahani E, Jalaie S. Comparing the gap in noise test results in patients with type 1 diabetes and normal subjects. Auditory and Vestibular Research 2018; 27(2): 57-64. [Persian]
Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971; 9(1): 97-113
Katz J, Burkard R, Hood L. Handbook of clinical Audiology. Sixthed Baltimore 2009; 584-607.
Uberall MA, Renner C, Edl S, Parzinger E, Wenzel D. VEP and ERP Abnormalities in Children and Adolescents with Prepubertal Onset of Insulin Dependent Diabetes Mellitus. Neuropediatrics 1996; 27(2): 88-93.
Kurita A, Mochio S, Isogai Y. Changes in auditory P300 event-related potentials and brainstem evoked potentials in diabetes mellitus. Acta Neurol Scand 1995; 92(4): 319-323.
Cooray GK, Maurex L, Brismar T. Cognitive impairment correlates to low auditory event-related potential amplitudes in type 1 diabetes. Psychoneuroendocrinology 2008; 33(7): 942-950.
Strachan MWJ, Ewing FME, Frier BM, McCrimmon RJ, Deary IJ. Effects of acute hypoglycaemia on auditory information processing in adults with Type I diabetes. Diabetologia 2003; 46(1): 97-105.
Zein‐Elabedein A, Abo El‐Fotoh WMM, Al Shourah WM, Moaty AS. Assessment of cognitive function in young children with type 1 diabetes mellitus using electrophysiological tests. Pediatric Diabetes 2022; 23(7): 1080-1087
Kumar K, Bhat J, Varghese A. Auditory Late Latency Response in Individuals with Type 2 Diabetes Mellitus. The Journal of International Advanced Otology 2018;14(3): 408
Tandon OP, Verma A, Ram BK. Cognitive dysfunction in NIDDM: P3 event related evoked potential study. Indian J Physiol Pharmacol 1999; 43(3): 383-388.
Seraji, H., Mohamadkhani, G., Taghavi, M., & Aarabi, S. (2024). Evaluation of Auditory Cortical Function in Type I Diabetic Patients by Auditory Late Latency Response. Journal of Paramedical Sciences & Rehabilitation, 12(4), 56-63. doi: 10.22038/jpsr.2024.76296.2577
MLA
H Seraji; Gh Mohamadkhani; M.R Taghavi; S Aarabi. "Evaluation of Auditory Cortical Function in Type I Diabetic Patients by Auditory Late Latency Response", Journal of Paramedical Sciences & Rehabilitation, 12, 4, 2024, 56-63. doi: 10.22038/jpsr.2024.76296.2577
HARVARD
Seraji, H., Mohamadkhani, G., Taghavi, M., Aarabi, S. (2024). 'Evaluation of Auditory Cortical Function in Type I Diabetic Patients by Auditory Late Latency Response', Journal of Paramedical Sciences & Rehabilitation, 12(4), pp. 56-63. doi: 10.22038/jpsr.2024.76296.2577
VANCOUVER
Seraji, H., Mohamadkhani, G., Taghavi, M., Aarabi, S. Evaluation of Auditory Cortical Function in Type I Diabetic Patients by Auditory Late Latency Response. Journal of Paramedical Sciences & Rehabilitation, 2024; 12(4): 56-63. doi: 10.22038/jpsr.2024.76296.2577