The Association between Central Corneal Thickness and Retinal Fiber Layer Thickness with Refractive Error

Document Type : Original Article

Authors

1 Msc student of optometry, Optometry department of Shahid Beheshti University of Medical Science, Tehran, Iran

2 Associate professor of department of Optometry, Iran University of Medical Science, Tehran, Iran

3 Assistant professor of department of Optometry, Shahid Beheshti University of Medical Science, Tehran, Iran

Abstract

Purpose:
The association between central corneal thickness and retinal fiber layer thickness with refractive error(emmetropic, myopic and hyperopic eyes).
Methods:
180 eyes (64 emmetropic eyes, 70 myopic eyes, 46 hyperopic eyes) in young subjects (18-35 years of age) were randomly selected. The participants in this study didn’t have any ocular pathology or any previous surgical history. Pachymetry pattern of RTVUE OCT in central corneal thickness (CCT) and retinal nerve fiber layer (RNFL) thickness were measured.
Results:
Mean CCT was 539.36 ± 36.37 microns. Emmetropic eyes had thinner corneas (emmetropic eyes: 536.14, myopic eyes: 539.67, hyperopic eyes: 543.28 microns). Myopic subjects had thinner RNFL thickness (myopic eyes: 114.21, emmetropic eyes: 121.05, hyperopic eyes: 120.45). Univariate analysis revealed that CCT is positively correlated with RNFL in hyperopic and myopic eyes.
Conclusion:
Our findings demonstrate that RNFL may have positively correlated with CCT in hyperopic and myopic eyes. RNFL had inversely correlated with the amount of myopia and positively correlated with hyperopia. CCT was not significantly correlated with refractive error.

Keywords

Main Subjects


1. Atchison, D. A, Markwell, E. L, Kasthurirangan, S., Pope, J. M., Smith, G. & Swann, P. G. Age-related changes in optical and biometric characteristics of emmetropic eyes. J Vis 2008; 8(4): 29.1-20. doi: 10.1167/8.4.29.
2. Wallman, J. & I Adams, J. Developmental aspects of experimental myopia in chicks: susceptibility, recovery and relation to emmetropization. Vision Res 1987 ;27(7): 1139-1163.
3. Tproilo, D. & Wallman, J. The regulation of eye growth and refractive state: an experimental study of emmetropization. Vision Res 1991; 31(7-8): 1237-50.
4. Cordonnier, M. & Dramaix, M. Screening for abnormal levels of hyperopia in children: a non-cycloplegic method with a hand held refractor. Br  j ophthalmol 1998; 82(11): 1260–1264.
5. Rudnicka, A. R., Owen, C. G., Nightingale, C. M., Cook, D. G. & Whincup, P. H. Ethnic differences in the prevalence of myopia and ocular biometry in 10-and 11-year-old children: the Child Heart and Health Study in England (Chase). Invest Ophthalmol Vis. Sci 2010; 51(12): 6270–6276.
6. Chang, P.-Y. & Chang, S.-W. Corneal Biomechanics, Optic Disc Morphology, and Macular Ganglion Cell Complex in Myopia. J glaucoma 2013; 22(5): 358-62.
 7. Yuen, L. H., He, M., Aung, T., Htoon, H. M., Tan, D. T. & Mehta, J. S. Biometry of the cornea and anterior chamber in Chinese eyes: an anterior segment optical coherence tomography study. Invest ophthalmol Vis. Sci 2010: 51(7); 3433-40.
8. LI, H., Leung, C. K. S., Wong, L., Cheung, C. Y. L., Pang, C. P., Weinreb, R. N. & Lam, D. S. C. Comparative study of central corneal thickness measurement with slit-lamp optical coherence tomography and visante optical coherence Tomography. Ophthalmology 2008; 115(5): 796-801.e2.
9. Shahidi, M., Wang, Z. & Zelkha, R. Quantitative thickness measurement of retinal layers imaged by optical coherence tomography. Am J Ophthalmol. 2005; 139(6): 1056-61.
10. Henderson, P. A., Medeiros, F. A., Zangwill, L. M. & Weinreb, R. N. Relationship between central corneal thickness and retinal nerve fiber layer thickness in ocular hypertensive patients. Ophthalmology 2005; 112(2): 251-6
11. Jonas, J., Nguyen, N. & Naumann, G. The retinal nerve fiber layer in normal eyes. Ophthalmology 1989; 96(5): 627-32.
12. Fishman, G. R., Pons, M. E., Seedor, J. A., Liebmann, J. M. & Ritch, R. Assessment of central corneal thickness using optical coherence tomography. J Cataract Refract Surg 2005; 31(4): 707-11.
13. Kaushik S, Gyatsho J, Jain R, Pandav SS, Gupta A. Correlation between retinal nerve fiber layer thickness and central corneal thickness in patients with ocular hypertension: an optical coherence tomography study. Am J Ophthalmol 2006; 141(5): 884-90. e2.

14. Quigley, H. A. & Addicks, E. M. Quantitative studies of retinal nerve fiber layer defects. Arch Ophthalmol 1982; 100(5): 807-14.

15. Hoyt,    W.  F.,   Frisen,  L.  &   Newman,    N.   M.
Fundoscopy of nerve fiber layer defects in glaucoma. Invest Ophthalmol Vis. Sci 1973; 12(11): 814-829 .
16. Hougaard, J. L., Ostenfeld, C., Heijl, A. & Bengtsson, B. Modelling the normal retinal nerve fibre layer thickness as measured by Stratus optical coherence tomography. Graefes Arch Clin Exp Ophthalmol  2006; 244(12):1607-14.
17. Budenz, D. L., Anderson, D. R., Varma, R., Schuman, J., Cantor, L., Savell, J., Greenfield, D. S., Patella, V. M., Quigley, H. A. & Tielsch, J. Determinants of normal retinal nerve fiber layer thickness measured by Stratus OCT. Ophthalmology 2007; 114(6): 1046-52
18. Rauscher, F. M., Sekhon, N., Feuer, W. J. & Budenz, D. L. Myopia affects retinal nerve fiber layer measurements as determined by optical coherence tomography. J Glaucoma 2009; 18(7): 501-5.
19. Göbel, W., Hartmann, F. & Haigis, W. Determination of retinal thickness in relation to the age and axial length using optical coherence tomography]. Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 2001; 98(2): 157-62.
20.  Choi, S.-W. & Lee, S.-J. Thickness changes in the fovea and peripapillary retinal nerve fiber layer depend on the degree of myopia. Korean J Ophthalmol 2006; 20(4): 215-9.
21. Pedersen, L., Hjortdal, J. & Ehlers, N. Central corneal thickness in high myopia. Acta Ophthalmol. Scand 2005; 83: 539–542.
22. Shimmyo, M. & Orloff, P. N. Corneal thickness and axial length. Am J Ophthalmol 2005; 139(3): 553-4.
23. Chen, M.-J., Liu, Y.-T., Tsai, C.-C., Chen, Y.-C., Chou, C.-K. & Lee, S.-M. Relationship between central corneal thickness, refractive error, corneal curvature, anterior chamber depth and axial length. J Chin Med Assoc 2009; 72(3): 133-7.

24. Kuo, N.-W., Shen, C.-J. & Sheu, S.-J. The ocular biometric and corneal topographic characteristics of   high-anisometropic  adults  in  Taiwan.  J  Chin Med Assoc 2011; 74(7): 310-5.
25. Henderson, P. A., Medeiros, F. A., Zangwill, L. M. & Weinreb, R. N. Relationship between central corneal thickness and retinal nerve fiber layer thickness in ocular hypertensive patients. Ophthalmology 2005; 112(2): 251-6.

26. MıSıR, R. & Sarıcaoglu, S. 2014. Investigation of the Relationship between Central Corneal Thickness and Retinal Nerve Fiber Layer Thickness in Ocular Hypertension. Acta Med Anatol 2014; 2(1): 1-5.