Effect of Corneal Cross-Linking on the Tear Osmolarity in Progressive Keratoconus Patients

Document Type : Original Article

Authors

1 MSc. Student of Optometry, School of Rehabilitation Sciences, Shahid Beheshti Medical University, Tehran, Iran

2 OD of Optometry, School of Rehabilitation, Shahid Beheshti University, Tehran, Iran

3 PhD Student of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran

4 Refractive errors research center, School of paramedical sciences, Mashhad University of Medical Sciences, Mashhad, Iran

5 MSc. Student of Statistic, School of rehabilitation, Shahid beheshty University of Medical Sciences, Tehran, Iran

6 Ophthalmologist, Farabi Hospital, Tehran University of Medical Sciences, Qazvin Square, South Karegar Street, Tehran, Iran

7 MSc. Student of Optometry, Refractive Error Eye, Optometrist at Farabi Eye Hospital, University of medical sciences, Tehran, Iran

Abstract

Purpose:
This study was conducted to assess the effect of corneal cross-linking on tear film osmolarity in patients with progressive keratoconus using the TearLab device.
Methods:
66 eyes of 66 patients including 40 men and 26 women with age range of 15 to 35 years old with progressive keratoconus who were candidates for corneal cross-linking surgery, were evaluated in this prospective study. These indicated patients for corneal cross-linking surgery had no history of eye or systemic disease associated with ocular manifestations. They hadn't worn contact lenses since 3 weeks before study and also they hadn't used drugs (effective on tear layer) or contact lenses for 6 months after surgery except their treatment period. Tear osmolarity was measured preoperatively and 6 months after surgery using the TearLab device. After all, data analysis was performed by descriptive and analytical statistical methods.
Results:
The mean Osmolarity before the corneal cross-linking surgery is 303.82±15.50 mOsm/L and after the surgery is 306.64±14.49 mOsm/L. There is no significant difference in tear film Osmolarity before and after the corneal cross-linking (P=0.192).
Conclusion:
Corneal cross-linking had no significant impact on tear film osmolarity in progressive keratoconus patients and we can’t consider dry eye as a side effect of corneal cross-linking.

Keywords

Main Subjects

References

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Journal of Paramedical Sciences & Rehabilitation
Volume 5, Issue 2
May 2016
Pages 7-13

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