ژن های کاندید و اثر محرومیت شنوایی در دوره بحرانی بر بیان ژن ها و ملکول ها در اختلال پردازش شنوایی

نوع مقاله : مقاله مروری

نویسندگان

1 استاد گروه شنوایی شناسی، دانشگاه علوم توانبخشی و سلامت اجتماعی، تهران، ایران

2 استادیار گروه شنوایی شناسی، دانشگاه علوم توانبخشی و سلامت اجتماعی، تهران، ایران

3 دانشجوی دکتری شنوایی شناسی، دانشگاه علوم توانبخشی و سلامت اجتماعی، تهران، ایران

چکیده

هدف:
هدف از این مطالعه بررسی مطالعات ژن های کاندید در اختلال پردازش شنوایی و مطالعات اثر محرومیت شنوایی در دوره بحرانی بر بیان ژن ها و ملکول های پروتئینی و تعیین نوع و محل آسیب و ماهیت اختلال پردازش شنوایی است.
روش بررسی:
در این مقاله مروری واژه های "ژن ها و اختلال پردازش شنوایی" و "محرومیت شنوایی و اختلال پردازش شنوایی" در منابع اطلاعاتی google scholar و science direct وpubmed و web of science در سال های 2000 تا 2023 جستجو شدند.
یافته ها:
پس از جستجو در منابع اطلاعاتی Google Scholar و Science Direct و pubmed و Web of Science، 16 مقاله مرتبط و جدید یافت شد.
نتیجه گیری:
پروتئین a2δ3 و ژن های kcna1 ,pax6 از جمله ملکول های شناخته شده موثر در اختلال پردازش شنوایی هستند. محرومیت شنوایی در دوره بحرانی با تغییر در بیان ژن های گیرنده های گلوتامات و گابا ، باعث نقص در رفتار های شنوایی بدون تاثیر بر آستانه های شنوایی می شود. شناسایی پروتئین ها و ملکول های موثر در اختلال پردازش شنوایی می تواند راهی برای تشخیص اختلال پردازش شنوایی باشد.

کلیدواژه‌ها

مراجع

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فصلنامه علمی- پژوهشی علوم پیراپزشکی وتوانبخشی
دوره 13، شماره 3
مهر 1403
صفحه 80-92

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