فصلنامه علمی- پژوهشی علوم پیراپزشکی وتوانبخشی

فصلنامه علمی- پژوهشی علوم پیراپزشکی وتوانبخشی

ژن های کاندید و اثر محرومیت شنوایی در دوره بحرانی بر بیان ژن ها و ملکول ها در اختلال پردازش شنوایی

نوع مقاله : مقاله مروری

نویسندگان
یونس لطفی 1
مسلم شعبانی 2
حمیده ارباب سرجو 3
1 استاد گروه شنوایی شناسی، دانشگاه علوم توانبخشی و سلامت اجتماعی، تهران، ایران
2 استادیار گروه شنوایی شناسی، دانشگاه علوم توانبخشی و سلامت اجتماعی، تهران، ایران
3 دانشجوی دکتری شنوایی شناسی، دانشگاه علوم توانبخشی و سلامت اجتماعی، تهران، ایران
10.22038/jpsr.2024.75288.2555
چکیده
هدف:
هدف از این مطالعه بررسی مطالعات ژن های کاندید در اختلال پردازش شنوایی و مطالعات اثر محرومیت شنوایی در دوره بحرانی بر بیان ژن ها و ملکول های پروتئینی و تعیین نوع و محل آسیب و ماهیت اختلال پردازش شنوایی است.
روش بررسی:
در این مقاله مروری واژه های "ژن ها و اختلال پردازش شنوایی" و "محرومیت شنوایی و اختلال پردازش شنوایی" در منابع اطلاعاتی google scholar و science direct وpubmed و web of science در سال های 2000 تا 2023 جستجو شدند.
یافته ها:
پس از جستجو در منابع اطلاعاتی Google Scholar و Science Direct و pubmed و Web of Science، 16 مقاله مرتبط و جدید یافت شد.
نتیجه گیری:
پروتئین a2δ3 و ژن های kcna1 ,pax6 از جمله ملکول های شناخته شده موثر در اختلال پردازش شنوایی هستند. محرومیت شنوایی در دوره بحرانی با تغییر در بیان ژن های گیرنده های گلوتامات و گابا ، باعث نقص در رفتار های شنوایی بدون تاثیر بر آستانه های شنوایی می شود. شناسایی پروتئین ها و ملکول های موثر در اختلال پردازش شنوایی می تواند راهی برای تشخیص اختلال پردازش شنوایی باشد.
کلیدواژه‌ها
اختلالات درک شنیداری
محرومیت حسی
ژن کاندید
جهش
  1. De Wit E, Visser-Bochane MI, Steenbergen B, Van Dijk P, et al. Characteristics of auditory processing disorders: A systematic review. J Speech Lang Hear Res 2016; 59(2): 384-413.
  2. Moore DR. Auditory processing disorder (APD)—Potential contribution of mouse research. Brain Res 2006; 1091(1): 200-206.
  3.  Dolphin AC. Voltage‐gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology. J Physiol 2016; 594(19): 5369-5390.
  4. Pirone A, Kurt S, Zuccotti A, Rüttiger L,et al. α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders. J Neurosci 2014; 34(2): 434-445.
  5. Simons-Weidenmaier NS, Weber M, Plappert CF, Pilz PK, et al. Synaptic depression and short-term habituation are located in the sensory part of the mammalian startle pathway. BMC neuroscience. 2006; 38(7):1-13.
  6. Bracic G, Hegmann K, Engel J, Kurt S. Impaired subcortical processing of amplitude-modulated tones in mice deficient for Cacna2d3, a risk gene for autism spectrum disorders in humans. eNeuro 2022; 9(2): 1-13.
  7. Guda P, Bourne PE, Guda C. Conserved motifs in voltage-sensing and pore-forming modules of voltage-gated ion channel proteins. Biochem Biophys Res Commun 2007; 352(2): 292-298.
  8. Allen PD, Ison JR. Kcna1 gene deletion lowers the behavioral sensitivity of mice to small changes in sound location and increases asynchronous brainstem auditory evoked potentials but does not affect hearing thresholds. J Neurosci. 2012; 32(7): 2538-2543.
  9. Thompson B, Davidson EA, Liu W, Nebert DW, et al. Overview of PAX gene family: analysis of human tissue-specific variant expression and involvement in human disease. Hum Genet 2021; 140(1): 381-400.
  10. Bamiou DE, Free SL, Sisodiya SM, Chong WK, et al.   Auditory   interhemispheric   transfer   deficits, hearing difficulties, and brain magnetic resonance imaging abnormalities in children with congenital aniridia due to PAX6 mutations. Arch Pediatr Adolesc Med 2007; 161(5): 463-469.
  11. Bobilev AM, Hudgens-Haney ME, Hamm JP, Oliver WT, et al. Early and late auditory information processing show opposing deviations in aniridia. Brain Research 2019; 1720: 146307.
  12. Marianowski R, Liao WH, Van Den Abbeele T, Fillit P, et al. Expression of NMDA, AMPA and GABAA receptor subunit mRNAs in the rat auditory brainstem. I. Influence of early auditory deprivation. Hear Res 2000; 150(1-2): 1-11.
  13. Paoletti P, Neyton J. NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol 2007; 7(1): 39-47.
  14. Kamalova A, Nakagawa T. AMPA receptor structure and auxiliary subunits. J Physiol. 2021; 599(2): 453-469.
  15. Ghit A, Assal D, Al-Shami AS, Hussein DE. GABAA receptors: structure, function, pharmacology, and related disorders. J Genet Eng Biotechnol 2021; 19(1): 123
  16. Qi Y, Yu S, Du Z, Qu T, et al. Long-term conductive auditory deprivation during early development causes irreversible hearing impairment and cochlear synaptic disruption. Neurosci 2019; 406: 345-355.
  17. Zhou M, Yuan J, Yan Z, Dai J, et al. Intrinsic and miniature postsynaptic current changes in rat principal neurons of the lateral superior olive after unilateral auditory deprivation at an early age. Neurosci 2020; 428: 2-12.
  18. Gillespie DC, Kim G, Kandler K. Inhibitory synapses in the developing auditory system are glutamatergic. Nat Neurosci 2005; 8(3): 332-338.
  19. Bi C, Cui Y, Mao Y, Dong S, et al. The effect of early auditory deprivation on the age-dependent expression pattern of NR2B mRNA in rat auditory cortex. Brain Res 2006; 1110(1): 30-38.
  20.  Lu J, Cui Y, Cai R, Mao Y, et al. Early auditory deprivation alters expression of NMDA receptor subunit NR1 mRNA in the rat auditory cortex. J Neurosci Res 2008; 86(6): 1290-1296.
  21. Mishra SK, Dey R. Unilateral auditory deprivation in humans: Effects on frequency discrimination and auditory memory span in the normal ear. Hear Res 2021;405: 108245.
  22. Truong DT, Che A, Rendall AR, Szalkowski CE, et al. Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability. Genes, Brain and Behavior 2014; 13(8): 802-811.
  23. Centanni TM, Booker AB, Chen F, Sloan AM, et al. Knockdown of dyslexia-gene Dcdc2 interferes with speech sound discrimination in continuous streams. J Neurosci 2016; 36(17): 4895-4906.
  24. Guidi LG, Mattley J, Martinez-Garay I, Monaco AP, et al. Knockout mice for dyslexia susceptibility gene homologs KIAA0319 and KIAA0319L have unaffected neuronal migration but display abnormal auditory processing. Cereb Cortex 2017; 27(12):5831-5845.
  25. Müller B, Schaadt G, Boltze J, Emmrich F, et al. ATP 2C2 and DYX 1C1 are putative modulators of dyslexia-related MMR. Brain Behav 2017;7(11):1-12.
  26. Rendall AR, Perrino PA, Buscarello AN, Fitch RH. Shank3B mutant mice display pitch discrimination enhancements and learning deficits. Int. J Dev Neurosci 2019; 72(1):13-21.
  27. Kurt S, Groszer M, Fisher SE, Ehret G. Modified sound-evoked brainstem potentials in Foxp2 mutant mice. Brain Res 2009; 1289(1): 30-36.
  28. Kurioka T, Mogi S, Yamashita T. Transient conductive hearing loss regulates cross-modal VGLUT expression in the cochlear nucleus of C57BL/6 mice. Brain Sci 2020; 10(5): 260.
  29. Kopp-Scheinpflug C, Tempel BL. Decreased temporal precision of neuronal signaling as a candidate mechanism of auditory processing disorder. Hear Res 2015; 330(Pt B): 213-220.
  30. Dawes P, Bishop DV, Sirimanna T, Bamiou DE. Profile and aetiology of children diagnosed with auditory processing disorder (APD). Int J Pediatr Otorhinolaryngol 2008; 72(4): 483-489.
  31. Lotfi Y, Moossavi A, Afshari PJ, Bakhshi E, et al. Spectro-temporal modulation detection and its relation to speech perception in children with auditory processing disorder. Int J Pediatr Otorhinolaryngol 2020; 131: 109860.
  32. Lotfi Y, Kargar S, Javanbakht M, Biglarian A. Development, validity and reliability of the Persian version of the consonant-vowel in white noise test. J Rehabil Sci Res 2016; 3(2): 29-34.
  33. Rezapour M, Abdollahi FZ, Delphi M, Lotfi Y, et al. Normalization and reliability evaluation of persian version of two-pair dichotic digits in 8 to 12-year-old children. IRJ. 2016; 14(2): 115-120. [Persian]
  34. Moossavi A, Lotfi Y, Javanbakht M, Faghihzadeh S. Speech-evoked auditory brainstem response; electrophysiological evidence of upper brainstem facilitative role on sound lateralization in noise. J Neurol Sci 2020; 41(1): 611-617.
  35. Moossavi A, Jafari Z, Lotfi Y, Malayeri S, et al. Correlation between Speech Evoked Auditory Brainstem Response and Gap in Noise Tests in 8-12 Year-Old Children with Central Auditory Processing Disorder. The Scientific Journal of Rehabilitation Medicine 2017; 6(4): 23-230.
  36. Abdollahi FZ, Lotfi Y, Moosavi A, Bakhshi E. Binaural interaction component of middle latency response in children suspected to central auditory processing disorder. Indian J Otolaryngol Head Neck Surg 2019; 71(2): 182-185.
  37. Arbab sarjoo H, Moossavi A, Javanbakht M, Bakhsh E, et al. Development and psychometric evaluation of Persian version of the quick speech in noise test in Persian speaking 18-25 years old normal adults. Journal of Rehabilitation Sciences & Research 2016; 3(3): 51-56.
  38. Lotfi Y, Moossavi A, Javanbakht M, Zadeh SF. Speech-ABR in contralateral noise: A potential tool to evaluate rostral part of the auditory efferent system. Med Hypotheses 2019; 132: 109355.
  39. Lotfi Y, Nazeri AR, Asgari A, Moosavi A, et al. Iranian version of speech, spatial, and qualities of hearing scale: a psychometric study. Acta Med Iran 2016; 54(12): 756-764.
فصلنامه علمی- پژوهشی علوم پیراپزشکی وتوانبخشی
دوره 13، شماره 3
پاییز 1403
صفحه 80-92